FIVU: The other trend in sciences today: limited laboratory, linear and animal bias, not that sexy for full human ( sample), even when detail driven by Tocris Biosciences:

"Potent TrkB agonist 4607 | LM 22A4 IC50 = 47 nM. Induces activation of Trk, Akt and ERK in mouse hippocampus and striatum. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome. Chemical Name: 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)
methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
 Biological Activity
Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases. Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline. Technical Data
M.Wt:275.31Formula:C17H13N3OSolubility:Soluble to 15 mM in DMSOPurity:>99 %Storage:Store at RTCAS No:504433-23-2The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

IT IS HARD TO IMMEDIATELY OUTSIDE OF THE NEU-ROBIO-CHEMISTRY SPECIALITY TO IDENTIFY THAT THIS ADVERTIZEMENT IS ABOUT THE SAME AGENT ( IT CAME TO MY BOX UNSOLICITED), MYSELF I DO HAVE NEUROSCIENCES BACKROUND.

"Trk ReceptorsMore Information ÂťTrk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCÎł signaling pathways. Four members of the Trk family have been identified.

Trk Receptor Products
Agonists Cat.No. Product Name / Activity 2837  BDNF (human)   Activates TrkB and p75 receptors  3826  7,8-Dihydroxyflavone   TrkB agonist  4607  LM 22A4    Potent TrkB agonist  Inhibitors Cat.No. Product Name / Activity 2617  AG 879   TrkA inhibitor  2238  GW 441756   Potent, selective TrkA inhibitor  3395  Lestaurtinib   TrkA, JAK2 and FLT3 inhibitor  2272  Ro 08-2750   Inhibits NGF binding to p75NTR and TrkA  Other Cat.No. Product Name / Activity 2087  NTR 368   p75NTR fragment; induces apoptosis  3051  TLQP 21   VGF-derived peptide  Related Categories
Growth Factor Receptors


AND WHAT IS THE PROBLEM - THAT IN OUR DAY AND TIME WE HAVE ENOUGH ACCES TO THYROSINE ACTIVITIES ( PRE-ENZYMATIC AGENT THAT DEVELOPES TO FULL TIME NEUROHORMON)IN A HUMAN.

AND WHAT THE PROBLEM - WE, THE HUMANS EXPERIENCE THE SAME PHYSIOLOGICAL CHANNEL VIA MUCH MORE INVOLVED MODULATION
( VIDE MOUTH BRAIN AND HUMAN BRAIN EVEN IN THE OPEN INTERNET)

I WOULD ARGUE THAT MY RECEPPTOR WHILE A SINEQUNON INITIAL GATE FOR THE SIGNAL IS GETTING OBLIVIOUS WITH WHAT HAPOPENS SUBSEQUENTLY. SO IS NEEDED BUT THAN COMPLETELY RUN OVER WITH WHAT IT COULD DO TO
ME, EVEN MIXING ME WITH THE MOUSE.  IT IS NOT SO WITH WHAT WE CALL IN THE HELPING PROFESSIONS VULNERABLE SUBJECTS AND VULNERABLE POPULATIONS.
THST IS WHY THE ASSESSMENT OF THE TREATMENT SITUATIONS FOR SUCH 'RESEACH' IS DONEE BY THE CLINICAL AND NOT BIOCHEMICAL STAFF AND OR CLINICAL TEAM.

THERE IS MORE THAT NEEDED TO BE INCLUDED IN THE RESEACH BUT PRIMARILY DATA ON HUMANS.  THE CAPACITY OF THE HUMAN TO PROCESS PHYSIOLOGICAL SIGNAL THE WAY THE WILLFULL BEHAVIOR ALLOWS FAR LEAVES BEHIND NOT EVEN A MOUSE BUT THE BIOCHEMISTS NOT EVEN MENTIONING  THE LIMITATION AND APPLICABILITY OF THE ISOLATED CHEMICAL AGENT. EVEN THYROSINE IS NOT SAME! THE ONE THAT STARTED THE RUN FROM THE MOUSE RECEPTOR GOES BACK THERE, O'K GENIUSES?

IS THYROSINE  ON A WAY OF INIATING THIS INTERACTION WITH ME IN MORE AMEABLE MANNER? YOU TELL SELF.